Gomisin N inhibits inflammatory cytokine production.
Hosokawa, Yoshitaka Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hosokawa, Ikuko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Shindo, Satoru Tokushima University
Ozaki, Kazumi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
periodontal ligament cells
Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-α-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-α-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert antiinflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-α-stimulated ERK and JNK pathways activation.
This is a post-peer-review, pre-copyedit version of an article published in Inflammation.
The final authenticated version is available online at: https://doi.org/10.1007/s10753-016-0482-4
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