Badr Badr, Hoida Ali Tokushima University
Kanemaru, Kaori Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Departmental Bulletin Paper
Rhamnan sulfate, one of sulfated polysaccharides from seaweeds, is considered to have various characteristics such as antioxidant, anticoagulant, anti-inflammatory, antitumor, contraceptive, and antiviral activities, for the treatment of several diseases. We examined the effect of rhamnan sulfate on thymic lymphocytes treated simultaneously with methylmercury chloride, a toxic organometallic compound, using a flow-cytometric techniques with fluorescent probes, fluo-3-AM (an indicator for intracellular Ca2+) and propidium iodide (an indicator for dead cells). Rhamnan sulfate attenuated the methylmercury-induced increase in cell lethality. This effect of rhamnan sulfate is supposed to be due to the attenuation of methylmercury-induced elevation of intracellular Ca2+ levels. Rhamnan sulfate may be useful for the prevention of organometallic intoxication.
Natural Science Research
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Bioscience and Bioindustry