| ID | 111004 |
| Author |
Fukunaga, Eri
The University of Tokushima
Ohiwa, Yurie
The University of Tokushima
Yamada, Mari
The University of Tokushima
Sumi, Ayaka
The University of Tokushima
Satoh, Masaya
The University of Tokushima
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| Keywords | N,N-dimethyldodecylamine-N-oxide (DDAO)
cytotoxicity
lymphocyte
|
| Content Type |
Departmental Bulletin Paper
|
| Description | N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.
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| Journal Title |
Natural Science Research
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| ISSN | 09146385
|
| NCID | AN10065859
|
| Volume | 29
|
| Issue | 1
|
| Start Page | 1
|
| End Page | 4
|
| Sort Key | 1
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| Published Date | 2015-01
|
| EDB ID | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Bioscience and Bioindustry
|
