No relationship exists between PBP 2a amounts expressed in different MRSA strains obtained clinically and their β-lactam MIC values

Parvez, Md. Anowar Khasru; Shibata, Hirofumi; Nakano, Tatsuro; Niimi, Shingo; Fujii, Nobuo; Arakaki, Naokatu; Higuti, Tomihiko

doi:10.2152/jmi.55.246

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ID	110867
Author	Parvez, Md. Anowar Khasru Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Shibata, Hirofumi Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers Nakano, Tatsuro Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Niimi, Shingo Division of Biological Chemistry and Biologicals, National Institute of Health Sciences Fujii, Nobuo Department of Media Design, Faculty of Human Life Sciences, Tokushima Bunri University Arakaki, Naokatu Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers Higuti, Tomihiko Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	Methicillin-resistant Staphylococcus aureus (MRSA) Penicillin-binding protein (PBP) 2a β-lactam MIC values
Content Type	Journal Article
Description	After establishing a linear relationship between the amount of penicillinbinding protein (PBP) 2a and membrane proteins of methicillin-resistant Staphylococcus aureus (MRSA) COL by dot-blot analysis using an antibody against PBP 2a, we determined the PBP 2a quantities in membrane fractions prepared from 14 different MRSA cells. Methicillin-sensitive S. aureus ATCC 6538P was used as a quality control strain. The amounts of PBP 2a diverged among the strains, and no relationship to β-lactam MIC values were observed in the corresponding strains.
Journal Title	The journal of medical investigation : JMI
ISSN	13431420
NCID	AA11166929
Volume	55
Issue	3-4
Start Page	246
End Page	253
Sort Key	246
Published Date	2008-08
EDB ID	193740
DOI (Published Version)	10.2152/jmi.55.246
URL ( Publisher's Version )	https://doi.org/10.2152/jmi.55.246
FullText File	jmi_55_3-4_246.pdf 792 KB
language	eng
TextVersion	Publisher
departments	Pharmaceutical Sciences