ID 111266
Title Alternative
2型糖尿病患者における非侵襲的皮下自家蛍光測定の動脈硬化の代替指標としての有用性の検証
Skin Autofluorescence and Atherosclerosis
Author
Temma, Jin Tokushima University
Horie, Toru Tenma Hospital
Keywords
skin autofluorescence
intima-media thickness
type 2 diabetes
atherosclerosis
Content Type
Thesis or Dissertation
Description
Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was recently reported to represent tissue AGEs accumulation with a non-invasive method. The aim of the present study was to evaluate association between AF value and diabetic vascular complications, such as retinopathy, nephropathy and cervical atherosclerosis using the carotid intima-media thickness (IMT), an established marker of cardiovascular disease in patients with type 2 diabetes. A total of 68 patients with type 2 diabetes were enrolled in a cross-sectional manner. AGEs accumulation was measured with AF reader. Clinical parameters were collected at the time of AF and IMT measurement. Max-IMT was correlated with age and AF (r=0.407, p=0.001), but not with HbA1c, GA, and pentosidine. Also, AF was not correlated with HbA1c, GA and pentosidine, but was correlated with age (r=0.560, p<0.001), duration of diabetes (r=0.256, p<0.05). Multivariate regression analysis revealed that AF, but not age, was an independent determinant of max-IMT. In conclusion, AF might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
AA12022913
Publisher
Faculty of Medicine Tokushima University
Volume
62
Issue
3-4
Start Page
126
End Page
129
Sort Key
126
Published Date
2015-08
Remark
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201505211009.pdf
論文本文 : LID201505211010.pdf
本論文は,著者Jin Temmaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第2803号
Diploma Number
甲医第1245号
Granted Date
2015-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Institute of Advanced Medical Sciences
Medical Sciences