ID 113501
Author
Hutami, Islamy Rahma Tokushima University
Keywords
Temporomandibular joint
Rheumatoid arthritis
Osteoclast
Fas
S1P1
NF-κB
Content Type
Journal Article
Description
Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P1 signaling via NF-kB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-kB subunit as a potential therapy for attenuating osteoclastogenesis.
Journal Title
Japanese Dental Science Review
ISSN
18827616
NCID
AA12334461
Publisher
Japanese Association for Dental Science|Elsevier
Volume
55
Issue
1
Start Page
12
End Page
19
Published Date
2018-10-26
Rights
© 2018 The Authors. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences