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ID 116888
Title Alternative
ベタヒスチンが一側内耳破壊後のラットの前庭代償に与える影響
Author
Matsuda, Kazunori Tokushima Prefectural Central Hospital KAKEN Search Researchers
Kitahara, Tadashi Nara Medical University
Matsuoka, Momoyo University of Tokushima
Keywords
vestibular compensation
betahistine dihydrochloride
medial vestibular nucleus
Fos
histamine H3 receptor
Content Type
Thesis or Dissertation
Description
Background: Vestibular compensation (VC) after unilateral labyrinthectomy (UL) consists of the initial and late processes. These processes can be evaluated based on the decline in the frequency of spontaneous nystagmus (SN) and the number of MK801-induced Fos-positive neurons in the contralateral medial vestibular nucleus (contra-MVe) in rats. Histamine H3 receptors (H3R) are reported to be involved in the development of VC. Objective: We examined the effects of betahistine, an H3R antagonist, on the initial and late processes of VC in UL rats. Methods: Betahistine dihydrochloride was continuously administered to the UL rats at doses of 100 and 200 mg/kg/day using an osmotic minipump. MK801 (1.0 mg/kg) was intraperitoneally administered on days 7, 10, 12, and 14 after UL, while Fos-positive neurons were immunohistochemically stained in the contra-MVe. Results: The SN disappeared after 42 h, and continuous infusion of betahistine did not change the decline in the frequency of SN. The number of MK801-induced Fos-positive neurons in contra-MVe significantly decreased on days 7, 10, and 12 after UL in a dose-dependent manner in the betahistine-treated rats, more so than in the saline-treated rats. Conclusion: These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats.
Journal Title
Brain Sciences
ISSN
20763425
Publisher
MDPI
Volume
11
Issue
3
Start Page
360
Published Date
2021-03-11
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Junya Fukudaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/ ).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3591号
Diploma Number
甲医第1519号
Granted Date
2022-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences