| ID | 111340 |
| Author |
Purwanti, Nunuk
The University of Tokushima|Gadjah Mada University
Azlina, Ahmad
The University of Tokushima
Karabasil, Mileva R
The University of Tokushima|Belgrade University
Hasegawa, Takahiro
The University of Tokushima
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Yao, Chenjuan
The University of Tokushima
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Akamatsu, Tetsuya
The University of Tokushima
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Hosoi, Kazuo
The University of Tokushima
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|
| Keywords | submandibular gland
IL-6
STAT3
duct-ligation
|
| Content Type |
Journal Article
|
| Description | Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker. Sca-1 expression increased prominently in almost all of cells in the duct system, except the acinar cells. Sca-1 induction was accompanied with phosphorylated-STAT3 (Y705) elevation, which was localized in the nuclei of all duct cells. Electrophoretic mobility shift assay (EMSA) confirmed the specific binding of STAT3 to the GAS sequence, a biding site of gamma interferon activating site. Present study suggested one of the initial steps of the tissue regeneration after injury includes STAT3 pathway.
|
| Journal Title |
The Journal of Medical Investigation
|
| ISSN | 13496867
13431420
|
| NCID | AA11166929
AA12022913
|
| Publisher | Faculty of Medicine Tokushima University
|
| Volume | 56
|
| Issue | Supplement
|
| Start Page | 253
|
| End Page | 254
|
| Sort Key | 253
|
| Published Date | 2009-12
|
| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Oral Sciences
Bioscience and Bioindustry
|
