Total for the last 12 months
number of access : ?
number of downloads : ?
ID 119107
Author
Yasui, Saya Anan Medical Center
Kaneko, Yousuke Anan Medical Center
Hosoki, Minae Anan Medical Center
Hori, Taiki Anan Medical Center|Tokushima University
Tani, Akihiro Anan Medical Center
Otoda, Toshiki Tokushima University
Keywords
dehydroepiandrosterone sulfate
presarcopenia
sarcopenia
dynapenia
type 2 diabetes
Content Type
Journal Article
Description
Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. Although skeletal muscle disorders are often found in diabetic people, the clinical significance of DHEAS in skeletal muscle remains unclear. Therefore, we aimed to determine whether DHEAS is associated with the development of skeletal muscle disorders in individuals with type 2 diabetes (T2D). A cross-sectional study was conducted in 361 individuals with T2D. Serum DHEAS levels, skeletal muscle mass index (SMI), handgrip strength (HS), and gait speed (GS) were measured in the participants. Pre-sarcopenia, sarcopenia, and dynapenia were defined according to the definitions of the AWGS 2019 criteria. DHEAS level was positively associated with HS but not with SMI or GS after adjustment of confounding factors. Multiple logistic regression analyses in total subjects showed that DHEAS level had an inverse association with the prevalence of dynapenia but not with the prevalence of pre-sarcopenia or sarcopenia. Furthermore, a significant association between DHEAS level and dynapenia was found in males but not in females. ROC curve analysis indicated that cutoff values of serum DHEAS for risk of dynapenia in males was 92.0 μg/dL. Therefore, in male individuals with T2D who have low serum levels of DHEAS, adequate exercise might be needed to prevent dynapenia.
Journal Title
Metabolites
ISSN
22181989
Publisher
MDPI
Volume
13
Issue
11
Start Page
1129
Published Date
2023-11-03
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences
Institute of Advanced Medical Sciences