ID | 119107 |
Author |
Yasui, Saya
Anan Medical Center
Kaneko, Yousuke
Anan Medical Center
Yamagami, Hiroki
Anan Medical Center|Tokushima University
Tokushima University Educator and Researcher Directory
Hosoki, Minae
Anan Medical Center
Hori, Taiki
Anan Medical Center|Tokushima University
Tani, Akihiro
Anan Medical Center
Nakamura, Shingen
Tokushima University
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Otoda, Toshiki
Tokushima University
Yuasa, Tomoyuki
Tokushima University
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Mori, Hiroyasu
Tokushima University
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Kuroda, Akio
Tokushima University
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Endo, Itsuro
Tokushima University
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Matsuhisa, Munehide
Tokushima University
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Soeki, Takeshi
Tokushima University
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Aihara, Ken-ichi
Anan Medical Center|Tokushima University
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|
Keywords | dehydroepiandrosterone sulfate
presarcopenia
sarcopenia
dynapenia
type 2 diabetes
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Content Type |
Journal Article
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Description | Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. Although skeletal muscle disorders are often found in diabetic people, the clinical significance of DHEAS in skeletal muscle remains unclear. Therefore, we aimed to determine whether DHEAS is associated with the development of skeletal muscle disorders in individuals with type 2 diabetes (T2D). A cross-sectional study was conducted in 361 individuals with T2D. Serum DHEAS levels, skeletal muscle mass index (SMI), handgrip strength (HS), and gait speed (GS) were measured in the participants. Pre-sarcopenia, sarcopenia, and dynapenia were defined according to the definitions of the AWGS 2019 criteria. DHEAS level was positively associated with HS but not with SMI or GS after adjustment of confounding factors. Multiple logistic regression analyses in total subjects showed that DHEAS level had an inverse association with the prevalence of dynapenia but not with the prevalence of pre-sarcopenia or sarcopenia. Furthermore, a significant association between DHEAS level and dynapenia was found in males but not in females. ROC curve analysis indicated that cutoff values of serum DHEAS for risk of dynapenia in males was 92.0 μg/dL. Therefore, in male individuals with T2D who have low serum levels of DHEAS, adequate exercise might be needed to prevent dynapenia.
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Journal Title |
Metabolites
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ISSN | 22181989
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Publisher | MDPI
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Volume | 13
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Issue | 11
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Start Page | 1129
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Published Date | 2023-11-03
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Rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
University Hospital
Medical Sciences
Institute of Advanced Medical Sciences
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