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ID 114079
Author
Afroz, Shaista Aligarh Muslim University
Dalanon, Junhel C. Tokushima University
Iwasa, Takuma Tokushima University
Waskitho, Arief Tokushima University
Keywords
Orofacial pain
Neuropathic pain
Sensory ganglia
Neurotransmitter
Glial cell
Cytokine
Content Type
Journal Article
Description
Neuropathic pain (NP) develops because of damage to the peripheral or central nervous system. It results in the hyperalgesia and allodynia. In the recent years, various researchers have studied the involvement of neuro-immune system in causing persistence of pain. The absence of synaptic contacts in the sensory ganglion makes them distinctive in terms of pain related signalling. In sensory ganglia, the neurotransmitters or the other modulators such as inflammatory substances produced by the ganglion cells, because of an injury, are responsible for the cross-excitation between neurons and neuron-glial interaction, thus affecting chemical transmission. This chemical transmission is considered mainly responsible for the chronicity and the persistent nature of neuropathic pain. This review examines the pain signalling due to neurotransmitter or cytokine release within the sensory ganglia. The specific areas focused on include: 1) the role of neurotransmitters released from the somata of sensory neurons in pain , 2) neuron-glia interaction and 3) role of cytokines in neuromodulation and pain.
Journal Title
Neuroscience & Biobehavioral Reviews
ISSN
01497634
NCID
AA00324096
AA11540934
Publisher
Elsevier
Volume
108
Start Page
393
End Page
399
Published Date
2019-11-27
Rights
© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version)
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FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences