ID | 112753 |
Title Alternative | 正常マウスにおける軸索HCN電流へ麻酔薬が及ぼす影響
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Author |
Banzrai, Chimeglkham
Tokushima University
Endo, Sachiko
Tokushima University
Takayasu, Hirokazu
Tokushima University
Mori, Atsuko
Tokushima University
Shimatani, Yoshimitsu
Tokushima University
Kaji, Ryuji
Tokushima University
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Keywords | Axonal excitability
Anesthetics
HCN channel
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Content Type |
Thesis or Dissertation
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Description | Objective: The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability.
Methods: Normal male mice were anesthetized by either isoflurane inhalation or a combination of medetomidine, midazolam, and butorphanol intraperitoneal injection (‘‘triple agents’’). Immediately after induction, the tail sensory nerve action potential was recorded and its excitability was monitored. Results: Under both anesthetic protocols, there was an interval excitability change by long hyperpolarizing currents. There was greater threshold reduction approximately 30 min post induction, in comparison to immediately post induction. Other excitability parameters were stable over time. Modeling suggested interval suppression of internodal H conductance or leak current. Conclusions: Anesthetic agents affected responses to long hyperpolarizing currents. Significance: Axonal excitability during intraoperative monitoring may be affected by anesthetic agents. Interpretation of interval excitability changes under anesthesia requires caution, especially with long hyperpolarizing currents. |
Journal Title |
Clinical Neurophysiology
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ISSN | 13882457
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NCID | AA11523403
AA11309888
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Publisher | Elsevier
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Volume | 126
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Issue | 10
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Start Page | 2033
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End Page | 2039
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Published Date | 2015-01-19
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yusuke Osakiの学位論文として提出され, 学位審査・授与の対象となっている。 |
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DOI (Published Version) | |
URL ( Publisher's Version ) | |
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language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3207号
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Diploma Number | 甲医第1381号
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Granted Date | 2018-09-13
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
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