Advances in 5-ALA-PDD of gastric cancer
Koizumi, Noriaki Kyoto Prefectural University of Medicine|Nishijin Hospital
Harada, Yoshinori Kyoto Prefectural University of Medicine
Minamikawa, Takeo Kyoto Prefectural University of Medicine Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tanaka, Hideo Kyoto Prefectural University of Medicine
Otsuji, Eigo Kyoto Prefectural University of Medicine
Takamatsu, Tetsuro Kyoto Prefectural University of Medicine
Lymph node metastasis
Photodynamic diagnosis based on 5-aminolevulinic acid-induced protoporphyrin IX has been clinically applied in many fields based upon its evidenced efficacy and adequate safety. In order to establish a personalized medicine approach for treating gastric cancer patients, rapid intraoperative detection of malignant lesions has become important. Feasibility of photodynamic diagnosis using 5-aminolevulinic acid for gastric cancer patients has been investigated, especially for the detection of peritoneal dissemination and lymph node metastasis. This method enables intraoperative real-time fluorescence detection of peritoneal dissemination, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy comparable to that of a current molecular diagnostics technique. Although several complicating issues still need to be resolved, such as the effect of tissue autofluorescence and the insufficient depth penetration of excitation light, this simple and rapid method has the potential to become a useful diagnostic tool for gastric cancer, as well as urinary bladder cancer and glioma.
World Journal of Gastroenterology
Baishideng Publishing Group Inc.
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|DOI (Published Version)|
|URL ( Publisher's Version )|
wjg_22_3_1289.pdf 1.31 MB
Science and Technology