| ID | 74520 |
| Title Transcription | イガクテキ オウヨウ ニ ムケタ サイキン ドクソ ニ ユライ スル キノウセイ ナノ バイオ ツール ノ サクセイ
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| Title Alternative | Development of Functional Nano-Bio Tool Derived from Bacterial Protein Toxin for Clinical Application
|
| Author |
Tabata, Atsushi
Department of Biological Science and Technology,Life System, Institute of Technology and Science, The University of Tokushima Graduate School
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Sakakura, Eriko
Graduate School of Advanced Technology and Science, The University of Tokushima
Tomoyasu, Toshifumi
Department of Biological Science and Technology,Life System, Institute of Technology and Science, The University of Tokushima Graduate School
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Nagamune, Hideaki
Department of Biological Science and Technology,Life System, Institute of Technology and Science, The University of Tokushima Graduate School
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|
| Keywords | Cholesterol-Dependent Cytolysin
Functional Protein Tool
Drug Delivery System
Clinical Application
Bacterial Protein Toxin
|
| Content Type |
Departmental Bulletin Paper
|
| Description | A novel functional protein tool derived from cholesterol-dependent cytolysin was developed and
its application for clinical field such as a drug delivery system was investigated. This tool is composed of both of a functional-domain to connect the drug carrier and a targeting-domain to recognize the target cell. The recombinant protein consisted of a lung tumor specific peptide, domain 1-3 of intermedilysin with an introduced disulphide-bond to block the conformational change and pore-formation, and domain 4 of Streptococcus mitis-derived human platelet aggregation factor, was prepared using bacterial-expression system then investigated its function. It was shown that the prepared protein tool could specifically deliver a model of drug-carrier vesicles to human lung tumor cells in vitro. This result suggests that the novel functional protein tool constructed in this study has the superior properties for clinical application. |
| Journal Title |
徳島大学大学院ソシオテクノサイエンス研究部研究報告
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| ISSN | 21859094
|
| NCID | AA12214889
|
| Volume | 54
|
| Start Page | 51
|
| End Page | 56
|
| Sort Key | 51
|
| Published Date | 2009
|
| FullText File | |
| language |
jpn
|
| departments |
Bioscience and Bioindustry
|
