| ID | 114971 |
| Author |
Kikuta, Satomi
Tohoku University|Japan Science and Technology Agency|Japan Society for the Promotion of Science
Nakamura, Yukiyo
Tokushima University
Yamamura, Yukio
Tokushima University
Tamura, Atsushi
Tohoku University|Japan Science and Technology Agency|Northwestern University
Homma, Noriyasu
Tohoku University
Yanagawa, Yuchio
Japan Science and Technology Agency|Gunma University
Tamura, Hajime
Tohoku University
Kasahara, Jiro
Tokushima University
Tokushima University Educator and Researcher Directory
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Osanai, Makoto
Tohoku University|Japan Science and Technology Agency
|
| Content Type |
Journal Article
|
| Description | We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson’s disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
|
| Journal Title |
Scientific Reports
|
| ISSN | 20452322
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| Publisher | Springer Nature
|
| Volume | 5
|
| Start Page | 12800
|
| Published Date | 2015-08-10
|
| Rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Pharmaceutical Sciences
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