number of access : ?
number of downloads : ?
ID 116126
Title Alternative
ABCA1 gene-physical activity interaction for HDL-C
Author
Nishida, Yuichiro Saga University
Hachiya, Tsuyoshi Iwate Medical University
Hara, Megumi Saga University
Shimanoe, Chisato Saga University
Tanaka, Keitaro Saga University
Sutoh, Yoichi Iwate Medical University
Shimizu, Atsushi Iwate Medical University
Hishida, Asahi Nagoya University
Tsukamoto, Mineko Nagoya University
Kadomatsu, Yuka Nagoya University
Oze, Isao Aichi Cancer Center Research Institute
Koyanagi, Yuriko N. Aichi Cancer Center Research Institute
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Koyama, Teruhide Kyoto Prefectural University of Medicine
Ibusuki, Rie Kagoshima University
Takezaki, Toshiro Kagoshima University
Ikezaki, Hiroaki Kyushu University
Furusyo, Norihiro Kyushu University
Takashima, Naoyuki Shiga University of Medical Science
Kadota, Aya Shiga University of Medical Science
Suzuki, Sadao Nagoya City University
Nakagawa-Senda, Hiroko Nagoya City University
Kuriki, Kiyonori University of Shizuoka
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Momozawa, Yukihide RIKEN
Kubo, Michiaki RIKEN
Nakatochi, Masahiro Nagoya University
Naito, Mariko Nagoya University|Hiroshima University
Wakai, Kenji Nagoya University
Keywords
epidemiology
exercise
genetics
high density lipoprotein-cholesterol
polymorphisms
cholesterol efflux
adenosine 5′-triphosphate binding cassette transporter A1
Content Type
Journal Article
Description
Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDL-C-related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-C-related SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β = 0.032) or high PA (β = 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.
Journal Title
Journal of Lipid Research
ISSN
00222275
NCID
AA00701215
Publisher
American Society for Biochemistry and Molecular Biology|Elsevier
Volume
61
Issue
1
Start Page
86
End Page
94
Published Date
2019-11-06
Rights
This is an Open Access article under the CC BY license(https://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences