number of access : ?
number of downloads : ?
ID 116245
Author
Tien, Nguyen Van Tokushima University
Hishida, Asahi Nagoya University
Tamura, Takashi Nagoya University
Kubo, Yoko Nagoya University
Tsukamoto, Mineko Nagoya University
Tanaka, Keitaro Saga University
Hara, Megumi Saga University
Takezaki, Toshiro Kagoshima University
Nishimoto, Daisaku Kagoshima University
Koyama, Teruhide Kyoto Prefectural University of Medicine
Ozaki, Etsuko Kyoto Prefectural University of Medicine
Suzuki, Sadao Nagoya City University
Nishiyama, Takeshi Nagoya City University
Kuriki, Kiyonori University of Shizuoka
Kadota, Aya Shiga University of Medical Science
Takashima, Naoyuki Shiga University of Medical Science|Kindai University
Ikezaki, Hiroaki Kyushu University
Murata, Masayuki Kyushu University
Oze, Isao Aichi Cancer Center Research Institute
Matsuo, Keitaro Aichi Cancer Center Research Institute|Nagoya University
Mikami, Haruo Chiba Cancer Center Research Institute
Nakamura, Yohko Chiba Cancer Center Research Institute
Takeuchi, Kenji Nagoya University
Wakai, Kenji Nagoya University
Keywords
dietary acid load
metabolic syndrome
net endogenous acid production
cross-sectional study
Content Type
Journal Article
Description
The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35–69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12–1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.
Journal Title
Nutrients
ISSN
20726643
Publisher
MDPI
Volume
12
Issue
6
Start Page
1605
Published Date
2020-05-29
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences