ヒトパルボウイルスB19による急性心不全が疑われた5症例の臨床的検討

The clinical and laboratory findings of 5 adult patients with recent human parvovirus B19 infection in Anan city （from January to February 2005） were reported. They showed local and generalized edema and/or arthritis. Clinical examinations showed relative neutrophilia with lymphcytopenia, anemia, hypocomlementemia in all patients and proteinuria with hematuria in 2 cases （No 2, 3）. Erythema were recognized in only 2 younger cases （No 3, 5）. Mean weight increase due to edema was 2.2Kg. All 5 patients were positive for human parvovirus B19 IgM/IgG antibody. After treatment, CTR decreased 8.0% on an average, and elevated BNP levels markedly declined one month later in 3 cases （No 2, 3, 4）. %FS also reduced in these cases, and one case （No 4） observed slight degree of echo free space （probably pericardial effusion）.
When human parvovirus B19 is prevalent, differential diagnosis of the symptoms such as anemia, dyspnea, oligouria and polyarthralgia are mandatory. If human parvovirus B19 infection is suspected, virus-related cardiomyopathy should be considered.

四国医学雑誌 : http://www.tokushima-u.ac.jp/med/research/shikoku_acta_medica.html