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ID 113595
Author
Siriwardena, B S M S Hiroshima University|University of Peradeniya
Ogawa, I Hiroshima University
Udagama, M N G P K University of Peradeniya
Tilakaratne, W M University of Peradeniya
Takata, Takashi Hiroshima University
Content Type
Journal Article
Description
Background: Nodal metastasis is a major prognostic indicator for oral squamous cell carcinoma (OSCC) progression. Recently, it has been revealed that lymphangiogenic growth factor VEGF-C and its receptor Flt-4 play an important role for invasion and metastasis in cancer cells.
Aim: To examine VEGF-C expression and its correlation with lymphatic status, including the number of lymph vessels and lymphatic invasion, tumour invasion and metastasis in OSCC.
Methods: Intratumoural and peritumoural lymphatic vessels were examined using D2-40 in 54 OSCC cases and correlated with VEGF-C expression and clinicopathological findings. The histological pattern of invasion and pathological findings were compared.
Results: High expression of VEGF-C was frequently observed in OSCC and was associated with increased number of lymph vessels and lymphatic invasion. VEGF-C was well correlated with invasion pattern and metastasis.
Conclusions: Results suggest that VEGF-C may play an important role for lymphangiogenesis and invasion in the metastatic process and can be a strong predicting factor for metastasis of OSCC.
Journal Title
Journal of Clinical Pathology
ISSN
14724146
00219746
NCID
AA00695564
Publisher
British Medical Association|The Association of Clinical Pathologists
Volume
61
Issue
1
Start Page
103
End Page
108
Published Date
2007-03-09
Rights
This article has been accepted for publication in Journal of Clinical Pathology, 2007 following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/jcp.2007.047662.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Oral Sciences