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ID 117439
Author
Ishikawa, Jun RIKEN|Tokyo University of Science
Takeo, Makoto RIKEN
Iwadate, Ayako Tokyo University of Science
Koya, Junko Tokyo University of Science
Kihira, Miho Tokyo University of Science
Suzuki, Yuki Tokyo University of Science
Taniguchi, Kazushi Tokyo University of Science
Kobayashi, Ayaka Tokyo University of Science
Tsuji, Takashi RIKEN|Tokyo University of Science
Content Type
Journal Article
Description
Organogenesis and regeneration are fundamental for developmental progress and are associated with morphogenesis, size control and functional properties for whole-body homeostasis. The liver plays an essential role in maintaining homeostasis of the entire body through various functions, including metabolic functions, detoxification, and production of bile, via the three-dimensional spatial arrangement of hepatic lobules and has high regenerative capacity. The regeneration occurs as hypertrophy, which strictly controls the size and lobule structure. In this study, we established a three-dimensional sinusoidal network analysis method and determined valuable parameters after partial hepatectomy by comparison to the static phase of the liver. We found that mechanical homeostasis, which is crucial for organ morphogenesis and functions in various phenomena, plays essential roles in liver regeneration for both initiation and termination of liver regeneration, which is regulated by cytokine networks. Mechanical homeostasis plays critical roles in the initiation and termination of organogenesis, tissue repair and organ regeneration in coordination with cytokine networks.
Journal Title
Communications Biology
ISSN
23993642
Publisher
Springer Nature
Volume
4
Start Page
409
Published Date
2021-04-07
Rights
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
cb_4_409.pdf 10.3 MB
language
eng
TextVersion
Publisher
departments
Oral Sciences