ID | 109521 |
Title Alternative | グルタミンは抗癌剤起因性腸炎モデルラットの小腸粘膜を保護する
Glutamine protects small intestinal mucosa
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Author |
Mawatari, Kazuaki
the University of Tokushima
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Takahashi, Akira
the University of Tokushima
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Nakaya, Yutaka
the University of Tokushima
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Asakura, Megumi
the University of Tokushima
Nakahashi, Mutsumi
the University of Tokushima
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Takizawa, Hiromitsu
the University of Tokushima
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Goto, Masakazu
the University of Tokushima
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Minato, Takuya
the University of Tokushima
Furukita, Yoshihito
the University of Tokushima
Yuasa, Yasuhiro
the University of Tokushima
Yamai, Hiromichi
the University of Tokushima
Seike, Junichi
the University of Tokushima
Tangoku, Akira
the University of Tokushima
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Keywords | glutamine
gastrointestinal toxity
anticancer drug
diamine oxidase
IgA
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Content Type |
Thesis or Dissertation
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Description | Supportive therapy during chemotherapy has become essential, but effective preventive therapies to gastrointestinal mucosal injury are few. We investigated the efficacy of glutamine in rat anticancer drug-induced enteritis model. In this study, we used twenty male SD rats. They were divided into control, 5-fluorouracil (5-FU) (orally administered at 20mg/kg day), 5-FU+glutamine (1000 mg/kg/day) and 5-FU+glutamine+fiber and oligosaccharide (GFO[○R]) (1000 mg/kg/day) groups. All groups were sacrificed on day 6 and upper jejunums were excised. The jejunal villous height was measured in specimens. IgA level in jejunal washing solution, and serum diamine oxidase activity were also measured. The jejunal villous height was recognized as shorter in the specimen from 5-FU treated rats compared with 5-FU+glutamine treated rats (p<0.001). Serum diamine oxidase activity in 5-FU+glutamine group were significantly superior to that in 5-FU group (p=0.028). IgA level in jejunal washing solution tended to be higher in 5-FU+glutamine group than that in 5-FU group (p=0.076). On the other hand, serum diamine oxidase activity and IgA level in jejunal washing solution showed no significant difference between 5-FU+GFO and 5-FU treatment group. Our results suggest that glutamine showed protective effects on mucosal injury of small intestine in rat anticancer drug-induced enteritis model.
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Journal Title |
The journal of medical investigation : JMI
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ISSN | 13431420
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NCID | AA11166929
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Volume | 61
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Issue | 1-2
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Start Page | 59
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End Page | 64
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Sort Key | 59
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Published Date | 2014-02
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Remark | 内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨 : LID201405131006.pdf 論文本文 : LID201405281003.pdf 本論文は,著者Hirokazu Takechiの学位論文として提出され,学位審査・授与の対象となっている。 |
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第2742号
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Diploma Number | 甲医第1203号
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Granted Date | 2014-03-19
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
University Hospital
Medical Sciences
Bioscience and Bioindustry
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