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ID 114404
Author
Shimomura, Yasuyuki Okayama University
Takaki, Akinobu Okayama University
Wada, Nozomu Okayama University
Yasunaka, Tetsuya Okayama University
Ikeda, Fusao Okayama University
Maruyama, Takayuki Okayama University
Tamaki, Naofumi The University of Tokushima KAKEN Search Researchers
Uchida, Daisuke Okayama University
Onishi, Hideki Okayama University
Kuwaki, Kenji Okayama University
Nakamura, Shinichiro Okayama University
Nouso, Kazuhiro Okayama University
Miyake, Yasuhiro Okayama University
Koike, Kazuko Okayama University
Tomofuji, Takaaki Okayama University
Morita, Manabu Okayama University
Yamamoto, Kazuhide Okayama University
Okada, Hiroyuki Okayama University
Keywords
antioxidant
non-alcoholic steatohepatitis
oxidative stress
Content Type
Journal Article
Description
Objective
Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic fatty liver disease (NAFLD) is also an oxidative stress-related disease. However, the oxidative/anti-oxidative balance has not been fully characterized in NAFLD. The objective of the present study was to investigate the balance between oxidative stress and the anti-oxidative activity in NAFLD, including non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC).
Patients
We recruited 69 patients with histologically proven NAFLD without HCC (NAFLD; n=58), and with NASH-related HCC (NASH-HCC; n=11). The 58 NAFLD patients included patients with non-alcoholic fatty liver (NAFL; n=14) and NASH (n=44).
Methods The serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY) were determined and then used to calculate the oxidative index. The correlations among such factors as ROM, OXY, oxidative index, and clinical characteristics were investigated.
Results
In NAFLD, ROM positively correlated with the body mass index (BMI), hemoglobin A1c (HbA1c), C-reactive protein (CRP), and the histological grade or inflammatory scores, while only high HbA1c and CRP levels were significant factors that correlated with a higher ROM according to a multivariate analysis. OXY positively correlated with the platelet counts, albumin, and creatinine levels, while negatively correlating with age. However, it improved after treatment intervention. The oxidative index positively correlated with BMI, CRP, and HbA1c. The NASH-HCC patients exhibited a lower OXY than the NASH patients, probably
due to the effects of aging.
Conclusion
Oxidative stress correlated with the levels of NASH activity markers, while the anti-oxidative function was preserved in younger patients as well as in patients with a well-preserved liver function. The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.
Journal Title
Internal Medicine
ISSN
13497235
Publisher
The Japanese Society of Internal Medicine
Volume
56
Issue
3
Start Page
243
End Page
251
Published Date
2017-02-01
Rights
The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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language
eng
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departments
Oral Sciences