| ID | 116485 |
| Author |
Nikawa, Takeshi
Tokushima University
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Ishidoh, Kazumi
Tokushima Bunri University
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| Keywords | MAFbx-1/atrogin-1
MuRF-1
Cbl-b
Cblin
Muscle atrophy
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| Content Type |
Journal Article
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| Description | This review focuses on the Cbl-b muscle atrophy-associated ubiquitin ligase and its inhibitors. Herein, the role of E3 ubiquitin ligase-associated muscle atrophy genes (atrogenes), including MAFbx-1/agrogin-1 and MuRF-1, as well as another ubiquitin ligase, Cbl-b and its inhibitors, is discussed. Cbl-b plays an important role in unloading muscle atrophy caused by spaceflight and in bedridden patients: Cbl-b ubiquitinated and induced the degradation of IRS-1, a key intermediate in the IGF-1 signaling. Furthermore, a pentapetpide (DGpYMP), inhibited Cbl-b-mediated IRS-1 ubiquitination. This peptide-based Cbl-b inhibitor Cblin and its homologous peptides in foods presumably affect muscle atrophy under such conditions.
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| Journal Title |
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
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| ISSN | 15709639
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| NCID | AA11685085
AA11966765
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| Publisher | Elsevier
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| Volume | 1868
|
| Issue | 11
|
| Start Page | 140495
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| Published Date | 2020-07-12
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| Rights | This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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