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ID 114858
Title Alternative
Tolerability and efficacy of a chemotherapy regimen avoiding Anthracycline for HER 2 positive elderly and poor risked breast cancer patients
高齢者乳癌に対するAnthracycline回避レジメン
Author
Tashiro, Yoshihiko Shikoku Central Hospital
Matsuyama, Kazuo Shikoku Central Hospital
Miyauchi, Takayuki Shikoku Central Hospital
Ishikawa, Masashi Shikoku Central Hospital
Sasa, Soichiro Tokushima University
Keywords
HER2 positive breast cancer
Elderly patients
Neo-adjuvant chemotherapy
RDI
pCR rate
Content Type
Journal Article
Description
Tolerability and efficacy of chemotherapy avoiding anthracycline regimen were examined histologically in ER negative and HER2positive elderly and poor risked breast cancer patients because of serious toxicity of Anthracycline regimen. Neo-adjuvant chemotherapy with 4 to 6 courses of Paclitaxel with Trastuzumab was given to 6 patients, Pertuzumab was added in 2 cases to obtain complete response. Adverse events were controllable, the primary treatment was completed without reducing the dose of drugs(RDI was 100%). Clinical CR rate was recognized in all 6 patients and pathological CR was proved in all of the operated5cases.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
76
Issue
1-2
Start Page
69
End Page
72
Sort Key
69
Published Date
2020-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences