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ID 115067
Author
Nakazeki, Fumiko Kyoto University
Tsuge, Itaru Kyoto University
Horie, Takahiro Kyoto University
Imamura, Keiko Kyoto University|RIKEN BioResource Center|RIKEN Center for Advanced Intelligence Project
Tsukita, Kayoko Kyoto University|RIKEN BioResource Center
Hotta, Akitsu Kyoto University
Baba, Osamu Kyoto University
Kuwabara, Yasuhide Kyoto University
Nishino, Tomohiro Kyoto University
Nakao, Tetsushi Kyoto University
Nishiga, Masataka Kyoto University
Nishi, Hitoo Kyoto University
Nakashima, Yasuhiro Kyoto University
Ide, Yuya Kyoto University
Koyama, Satoshi Kyoto University
Kimura, Masahiro Kyoto University
Tsuji, Shuhei Kyoto University
Naitoh, Motoko Kyoto University
Suzuki, Shigehiko Kyoto University
Kimura, Takeshi Kyoto University
Inoue, Haruhisa Kyoto University|RIKEN BioResource Center|RIKEN Center for Advanced Intelligence Project
Ono, Koh Kyoto University
Content Type
Journal Article
Description
Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic target for the treatment of atherosclerosis. Here, we show that SPAST, which encodes a microtubule-severing protein called SPASTIN, was a novel target gene of miR-33 in human. Actually, the miR-33 binding site in the SPAST 3′-UTR is conserved not in mice but in mid to large mammals, and it is impossible to clarify the role of miR-33 on SPAST in mice. We demonstrated that inhibition of miR-33a, a major form of miR-33 in human neurons, via locked nucleic acid (LNA)-anti-miR ameliorated the pathological phenotype in hereditary spastic paraplegia (HSP)-SPG4 patient induced pluripotent stem cell (iPSC)-derived cortical neurons. Thus, miR-33a can be a potential therapeutic target for the treatment of HSP-SPG4.
Journal Title
Clinical Science
ISSN
01435221
14708736
NCID
AA00143386
Publisher
Portland Press
Volume
133
Issue
4
Start Page
583
End Page
595
Published Date
2019-02-22
Rights
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND)(https://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version)
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language
eng
TextVersion
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departments
University Hospital
Medical Sciences