Hagiya, H. Osaka University
Koyama, T. Okayama University
Zamami, Yoshito Tokushima University KAKEN Search Researchers
Minato, Y. University of Minnesota
Tatebe, Y. Okayama University
Mikami, N. Chiba University
Teratani, Y. Okayama University
Ohshima, A. Okayama University
Shinomiya, K. Okayama University|Smile Co., Ltd.
Kitamura, Y. Okayama University
Sendo, T. Okayama University
Hinotsu, S. Sapporo Medical University
Tomono, K. Osaka University
Kano, M. R. Okayama University|University of Tokyo
Japan is still a medium-burden tuberculosis (TB) country. We aimed to examine trends in newly notified active TB incidence and TB-related mortality in the last two decades in Japan. This is a population-based study using Japanese Vital Statistics and Japan Tuberculosis Surveillance from 1997 to 2016. We determined active TB incidence and mortality rates (per 100 000 population) by sex, age and disease categories. Joinpoint regression was applied to calculate the annual percentage change (APC) in age-adjusted mortality rates and to identify the years showing significant trend changes. Crude and age-adjusted incidence rates reduced from 33.9 to 13.9 and 37.3 to 11.3 per 100 000 population, respectively. Also, crude and age-adjusted mortality rates reduced from 2.2 to 1.5 and 2.8 to 1.0 per 100 000 population, respectively. Average APC in the incidence and mortality rates showed significant decline both in men (−6.2% and −5.4%, respectively) and women (−5.7% and −4.6%, respectively). Age-specific analysis demonstrated decreases in incidence and mortality rates for every age category, except for the incidence trend in the younger population. Although trends in active TB incidence and mortality rates in Japan have favourably decreased, the rate of decline is far from achieving TB elimination by 2035.
Epidemiology and Infection
Cambridge University Press
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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