Are multifocal motor neuropathy patients underdiagnosed? : An epidemiological survey in Japan

Miyashiro, Ai; Matsui, Naoko; Shimatani, Yoshimitsu; Nodera, Hiroyuki; Izumi, Yuishin; Kuwabara, Satoshi; Imai, Tomihiro; Baba, Masayuki; Komori, Tetsuo; Sonoo, Masahiro; Mezaki, Takahiro; Kawamata, Jun; Hitomi, Takefumi; Kohara, Nobuo; Arimura, Kimiyoshi; Hashimoto, Shuji; Arisawa, Kokichi; Kusunoki, Susumu; Kaji, Ryuji

doi:10.1002/mus.23930

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Use this link to cite this item : https://repo.lib.tokushima-u.ac.jp/105906

ID	105906
Title Alternative	多巣性運動ニューロパチーは過少診断されているのか？ : 日本の疫学調査 Multifocal Motor Neuropathy
Author	Miyashiro, Ai Tokushima University KAKEN Search Researchers Matsui, Naoko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Shimatani, Yoshimitsu Tokushima University Nodera, Hiroyuki Tokushima University KAKEN Search Researchers Izumi, Yuishin Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Kuwabara, Satoshi Japanese Multifocal Motor Neuropathy Study Group Imai, Tomihiro Japanese Multifocal Motor Neuropathy Study Group Baba, Masayuki Japanese Multifocal Motor Neuropathy Study Group Komori, Tetsuo Japanese Multifocal Motor Neuropathy Study Group Sonoo, Masahiro Japanese Multifocal Motor Neuropathy Study Group Mezaki, Takahiro Japanese Multifocal Motor Neuropathy Study Group Kawamata, Jun Japanese Multifocal Motor Neuropathy Study Group Hitomi, Takefumi Japanese Multifocal Motor Neuropathy Study Group Kohara, Nobuo Japanese Multifocal Motor Neuropathy Study Group Arimura, Kimiyoshi Japanese Multifocal Motor Neuropathy Study Group Hashimoto, Shuji Fujita Health University School of Medicine Arisawa, Kokichi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers Kusunoki, Susumu Kinki University Kaji, Ryuji Tokushima University\|Japanese Multifocal Motor Neuropathy Study Group Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords	multifocal motor neuropathy amyotrophic lateral sclerosis diagnosis conduction block prevalence
Content Type	Thesis or Dissertation
Description	Objective: Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. Methods: In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. Results: The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. Conclusions: The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.
Journal Title	Muscle & Nerve
ISSN	10974598
NCID	AA11625800
Publisher	Wiley Periodicals
Volume	49
Issue	3
Start Page	357
End Page	361
Published Date	2013-07-08
Remark	内容要旨・審査要旨・論文本文の公開: 内容要旨・審査要旨 : LID201310221001.pdf 論文本文 : LID201407091001.pdf Submitted Version (preprint) 本論文は, 著者Ai Miyashiroの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID	288179
DOI (Published Version)	10.1002/mus.23930
URL ( Publisher's Version )	https://doi.org/10.1002/mus.23930
FullText File	LID201310221001.pdf 178 KB LID201407091001.pdf 543 KB
language	eng
TextVersion	ETD
MEXT report number	甲第2629号
Diploma Number	甲医第1172号
Granted Date	2013-09-12
Degree Name	Doctor of Medical Science
Grantor	Tokushima University
departments	University Hospital Medical Sciences