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ID 117377
Title Alternative
すべての胚移植に全胚凍結法が必要か。プロゲステロン上昇を伴わない新鮮胚移植は、凍結融解胚移植と同等の妊娠率をもたらす
A freeze-all strategy is not necessary for all embryo transfers
Author
Abe, Masami Tokushima University
Noguchi, Hiroki Tokushima University
Tamura, Kou Tokushima University
Aoki, Hidenori Tokushima University
Takeda, Asuka Tokushima University
Minato, Saki Tokushima University
Tachibana, Ayaka Tokushima University
Keywords
freeze-all
fresh embryo transfer
progesterone level
Content Type
Thesis or Dissertation
Description
Objectives : It has been suggested that the clinical outcomes of frozen-thawed embryo transfer (ET) are superior to those of fresh embryo transfer. We examined whether a freeze-all strategy is necessary for all embryo transfers, and, if not, to evaluate the conditions in which the pregnancy rates of fresh embryo transfer and frozen-thawed ET did not differ. Methods : Patients who underwent blastocyst transfer at Tokushima University Hospital between 2008 and 2019 were enrolled. The clinical outcomes and clinical characteristics of 1,022 patients that underwent fresh embryo transfer and 1,728 patients that underwent frozen-thawed ET were examined retrospectively. We considered the factors that influenced the pregnancy outcomes of fresh embryo transfer. Results : The frozen-thawed ET group exhibited significantly higher pregnancy, live-birth, and miscarriage rates than the fresh embryo transfer group. In the fresh embryo transfer group, a high progesterone level on the day of the human chorionic gonadotropin (hCG) trigger and lower grade embryos were risk factors for a low pregnancy rate. However, in the cases in which the progesterone level was < 1.0 ng / mL the pregnancy rate was equal to that of frozen-thawed ET. Conclusions : A freeze-all strategy is not necessary for embryo transfers, but should be employed in cases involving pre-ovulatory progesterone elevation.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
69
Issue
3-4
Start Page
224
End Page
229
Sort Key
224
Published Date
2022-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Masami Abeの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3645号
Diploma Number
甲医第1538号
Granted Date
2022-07-28
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital