ID | 116390 |
Title Alternative | Proteasomes in the Thymus
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Author |
Frantzeskakis, Melina
National Cancer Institute
Takahama, Yousuke
National Cancer Institute
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Ohigashi, Izumi
University of Tokushima
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Keywords | thymus
TEC
thymoproteasome
immunoproteasome
thymic selection
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Content Type |
Journal Article
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Description | The thymus provides a microenvironment that supports the generation and selection of T cells. Cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells (mTECs) are essential components of the thymic microenvironment and present MHC-associated self-antigens to developing thymocytes for the generation of immunocompetent and self-tolerant T cells. Proteasomes are multicomponent protease complexes that degrade ubiquitinated proteins and produce peptides that are destined to be associated with MHC class I molecules. cTECs specifically express thymoproteasomes that are essential for optimal positive selection of CD8+ T cells, whereas mTECs, which contribute to the establishment of self-tolerance in T cells, express immunoproteasomes. Immunoproteasomes are also detectable in dendritic cells and developing thymocytes, additionally contributing to T cell development in the thymus. In this review, we summarize the functions of proteasomes expressed in the thymus, focusing on recent findings pertaining to the functions of the thymoproteasomes and the immunoproteasomes.
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Journal Title |
Frontiers in Immunology
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ISSN | 16643224
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Publisher | Frontiers Media S.A.
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Volume | 12
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Start Page | 646209
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Published Date | 2021-03-19
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Rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)(https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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language |
eng
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departments |
Institute of Advanced Medical Sciences
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