| ID | 116454 |
| Title Alternative | Polymorphisms and Body Mass Index Across Life Course
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| Author |
Iwase, Madoka
Aichi Cancer Center Research Institute|Nagoya University
Matsuo, Keitaro
Aichi Cancer Center Research Institute|Nagoya University
Nakatochi, Masahiro
Nagoya University
Oze, Isao
Aichi Cancer Center Research Institute
Ito, Hidemi
Aichi Cancer Center Research Institute|Nagoya University
Koyanagi, Yuriko
Aichi Cancer Center Research Institute
Ugai, Tomotaka
Aichi Cancer Center Research Institute
Kasugai, Yumiko
Aichi Cancer Center Research Institute
Hishida, Asahi
Nagoya University
Takeuchi, Kenji
Nagoya University
Okada, Rieko
Nagoya University
Kubo, Yoko
Nagoya University
Shimanoe, Chisato
Saga University
Tanaka, Keitaro
Saga University
Ikezaki, Hiroaki
Kyushu University
Murata, Masayuki
Kyushu University
Takezaki, Toshiro
Kagoshima University
Nishimoto, Daisaku
Kagoshima University
Kuriyama, Nagato
Kyoto Prefectural University of Medicine
Ozaki, Etsuko
Kyoto Prefectural University of Medicine
Suzuki, Sadao
Nagoya City University
Watanabe, Miki
Nagoya City University
Mikami, Haruo
Chiba Cancer Center Research Institute
Nakamura, Yohko
Chiba Cancer Center Research Institute
Katsuura-Kamano, Sakurako
Tokushima University
Tokushima University Educator and Researcher Directory
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Kuriki, Kiyonori
University of Shizuoka
Kita, Yoshikuni
Tsuruga Nursing University
Takashima, Naoyuki
Kindai University
Nagino, Masato
Nagoya University
Momozawa, Yukihide
RIKEN
Kubo, Michiaki
RIKEN
Wakai, Kenji
Nagoya University
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| Keywords | obesity
body mass index
genome wide association study
polymorphisms
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| Content Type |
Journal Article
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| Description | Background: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities.
Methods: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models. Results: We found a significant association (P < 0.05/282 = 1.77 × 10−4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained, even after additional adjustment for dietary energy intake. Conclusions: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways. |
| Journal Title |
Journal of Epidemiology
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| ISSN | 13499092
09175040
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| NCID | AA10952696
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| Publisher | Japan Epidemiological Association
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| Volume | 31
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| Issue | 3
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| Start Page | 172
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| End Page | 179
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| Published Date | 2021-03-05
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| Rights | This is an open access article distributed under the terms of Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
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| language |
eng
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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