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ID 117569
Author
Hama, Susumu Musashino University
Kirimura, Naoko Kyoto Pharmaceutical University
Obara, Aki Kyorin University
Takatsu, Hirokatsu Kyorin University
Keywords
α-tocopherol
tocopheryl phosphate
tocopheryl succinate
rheumatoid arthritis
Content Type
Journal Article
Description
Anti-rheumatoid arthritis (RA) effects of α-tocopherol (α-T) have been shown in human patients in a double-blind trial. However, the effects of α-T and its derivatives on fibroblast-like synoviocytes (FLS) during the pathogenesis of RA remain unclear. In the present study, we compared the expression levels of genes related to RA progression in FLS treated with α-T, succinic ester of α-T (TS), and phosphate ester of α-T (TP), as determined via RT-PCR. The mRNA levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase (MMP)-3, and MMP-13 were reduced by treatment with TP without cytotoxicity, while α-T and TS did not show such effects. Furthermore, intraperitoneal injection of TP ameliorated the edema of the foot and joint and improved the arthritis score in laminarin-induced RA model mice. Therefore, TP exerted anti-RA effects through by inhibiting RA-related gene expression.
Journal Title
Molecules
ISSN
14203049
Publisher
MDPI
Volume
27
Issue
4
Start Page
1425
Published Date
2022-02-20
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
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language
eng
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departments
Pharmaceutical Sciences