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ID 115639
Title Alternative
達成可能及び残り一つを除いて達成可能な線量体積・平均線量制約に基づく計画のための強度変調放射線治療の最適化
Author
Nakada, Ryosei Tokushima University
Abou Al-Ola, Omar M. Tanta University
Keywords
IMRT optimization
nonlinear dynamical system
Lyapunov theorem
Content Type
Thesis or Dissertation
Description
We give a novel approach for obtaining an intensity-modulated radiation therapy (IMRT) optimization solution based on the idea of continuous dynamical methods. The proposed method, which is an iterative algorithm derived from the discretization of a continuous-time dynamical system, can handle not only dose-volume but also mean-dose constraints directly in IMRT treatment planning. A theoretical proof for the convergence to an equilibrium corresponding to the desired IMRT planning is given by using the Lyapunov stability theorem. By introducing the concept of “acceptable,” which means the existence of a nonempty set of beam weights satisfying the given dose-volume and mean-dose constraints, and by using the proposed method for an acceptable IMRT planning, one can resolve the issue that the objective and evaluation are different in the conventional planning process. Moreover, in the case where the target planning is totally unacceptable and partly acceptable except for one group of dose constraints, we give a procedure that enables us to obtain a nearly optimal solution close to the desired solution for unacceptable planning. The performance of the proposed approach for an acceptable or unacceptable planning is confirmed through numerical experiments simulating a clinical setup.
Journal Title
Computational and Mathematical Methods in Medicine
ISSN
1748670X
17486718
NCID
AA12129393
Publisher
Hindawi
Volume
2020
Start Page
3096067
Published Date
2020-09-03
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Ryosei Nakadaの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
Copyright © 2020 Ryosei Nakada et al. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3475号
Diploma Number
甲保第45号
Granted Date
2021-02-18
Degree Name
Doctor of Health Science
Grantor
Tokushima University
departments
Medical Sciences