number of access : ?
number of downloads : ?
ID 115601
Koshiyama, Daisuke The University of Tokyo
Fukunaga, Masaki National Institute for Physiological Sciences
Okada, Naohiro The University of Tokyo
Morita, Kentaro The University of Tokyo
Nemoto, Kiyotaka University of Tsukuba
Usui, Kaori The University of Tokyo
Yamamori, Hidenaga Osaka University
Yasuda, Yuka Life Grow Brilliant Mental Clinic|National Center of Neurology and Psychiatry
Fujimoto, Michiko Osaka University
Kudo, Noriko National Center of Neurology and Psychiatry
Azechi, Hirotsugu Osaka University
Watanabe, Yoshiyuki Osaka University
Hashimoto, Naoki Hokkaido University
Narita, Hisashi Hokkaido University
Kusumi, Ichiro Hokkaido University
Ohi, Kazutaka Kanazawa Medical University
Shimada, Takamitsu Kanazawa Medical University
Kataoka, Yuzuru Kanazawa Medical University
Yamamoto, Maeri Nagoya University
Ozaki, Norio Nagoya University
Okada, Go Hiroshima University
Okamoto, Yasumasa Hiroshima University
Harada, Kenichiro Yamaguchi University
Matsuo, Koji Saitama Medical University
Yamasue, Hidenori Hamamatsu University School of Medicine
Abe, Osamu The University of Tokyo
Hashimoto, Ryuichiro Showa University
Takahashi, Tsutomu University of Toyama
Hori, Tomoki Kyoto University
Onitsuka, Toshiaki Kyushu University
Holleran, Laurena National University of Ireland Galway
Jahanshad, Neda University of Southern California
van Erp, Theo G. M. University of California Irvine
Turner, Jessica Georgia State University
Donohoe, Gary National University of Ireland Galway
Thompson, Paul M. University of Southern California
Kasai, Kiyoto The University of Tokyo
Hashimoto, Ryota Osaka University|National Center of Neurology and Psychiatry
Content Type
Journal Article
Identifying both the commonalities and differences in brain structures among psychiatric disorders is important for understanding the pathophysiology. Recently, the ENIGMA-Schizophrenia DTI Working Group performed a large-scale meta-analysis and reported widespread white matter microstructural alterations in schizophrenia; however, no similar cross-disorder study has been carried out to date. Here, we conducted mega-analyses comparing white matter microstructural differences between healthy comparison subjects (HCS; N = 1506) and patients with schizophrenia (N = 696), bipolar disorder (N = 211), autism spectrum disorder (N = 126), or major depressive disorder (N = 398; total N = 2937 from 12 sites). In comparison with HCS, we found that schizophrenia, bipolar disorder, and autism spectrum disorder share similar white matter microstructural differences in the body of the corpus callosum; schizophrenia and bipolar disorder featured comparable changes in the limbic system, such as the fornix and cingulum. By comparison, alterations in tracts connecting neocortical areas, such as the uncinate fasciculus, were observed only in schizophrenia. No significant difference was found in major depressive disorder. In a direct comparison between schizophrenia and bipolar disorder, there were no significant differences. Significant differences between schizophrenia/bipolar disorder and major depressive disorder were found in the limbic system, which were similar to the differences in schizophrenia and bipolar disorder relative to HCS. While schizophrenia and bipolar disorder may have similar pathological characteristics, the biological characteristics of major depressive disorder may be close to those of HCS. Our findings provide insights into nosology and encourage further investigations of shared and unique pathophysiology of psychiatric disorders.
Journal Title
Molecular Psychiatry
Springer Nature
Start Page
End Page
Published Date
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
DOI (Published Version)
URL ( Publisher's Version )
FullText File
University Hospital