| ID | 112090 |
| Title Alternative | Suppression of human immunodeficiency virus type 1 replication by its mutants
変異体によるHIV-1の複製抑制
|
| Author |
Adachi, Akio
The University of Tokushima
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Inubushi, Ritsuko
The University of Tokushima
Shimano, Reika
The University of Tokushima
|
| Keywords | HIV-1
Gag
Env
gene therapy
|
| Content Type |
Journal Article
|
| Description | Various mutants of human immunodeficiency type 1 (HIV-1) were systematically analyzed with respect to their ability to suppress the replication of wild-type (wt) HIV-1. A total of thirty-six mutants of all nine HIV-1 genes were evaluated for their inhibitory effects in a single-round of viral replication cycle. Some of the gag and env mutants were found to be efficiently interfere with the replication of wt HIV-1. The effective sites were mapped to early and/or late viral replication phase. These mutants are useful for future gene therapy against HIV-1 disease AIDS.
|
| Journal Title |
Shikoku Acta Medica
|
| ISSN | 00373699
|
| NCID | AN00102041
|
| Publisher | 徳島医学会
|
| Volume | 54
|
| Issue | 4
|
| Start Page | 282
|
| End Page | 287
|
| Sort Key | 282
|
| Published Date | 1998-08-25
|
| FullText File | |
| language |
jpn
|
| TextVersion |
Publisher
|
| departments |
Medical Sciences
|
