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ID 114726
Title Alternative
リン負荷指数は、食事性リン負荷の新たな評価指標である : 食品を用いたアプローチ
PHOSPHATEMIC INDEX EVALUATES PHOSPHORUS LOAD
Author
Narasaki, Yoko Tokushima University|Japan Society for the Promotion of Science
Yamasaki, Michiyo Tokushima University
Matsuura, Sayaka Tokushima University
Morinishi, Mayumi Tokushima University
Nakagawa, Tomomi Tokushima University
Matsuno, Mami Tokushima University
Katsumoto, Misaki Tokushima University
Nii, Sachi Tokushima University
Fushitani, Yuka Tokushima University
Sugihara, Kohei Tokushima University
Noda, Tsuneyuki Otsuka Pharmaceutical Co., Ltd
Yoneda, Takeshi Otsuka Pharmaceutical Co., Ltd|Kio University
Keywords
Phosphatemix Index
Dietary phosphorus bioavailability
Crossover study
Whole-foods approach
Content Type
Thesis or Dissertation
Description
Objective: Dietary phosphorus (P) restriction is crucial to treat hyperphosphatemia and reduce cardiovascular disease risk and mortality in patients with chronic kidney disease (CKD) and the wider population. Various methods for dietary P restriction exist, but the bioavailability of P in food should also be considered when making appropriate food choices to maintain patients’ quality of life. Here, we propose the ‘‘Phosphatemic Index’’ (PI) as a novel tool for evaluating dietary P load based on P bioavailability; we also evaluated the effect of continuous intake of different PI foods in mixed meals on serum intact fibroblast growth factor 23 concentration.
Design and Methods: A 2-stage crossover study was conducted: Study 1: 20 healthy participants consumed 10 different foods containing 200 mg of P, and the PI was calculated from the area under the curve of a time versus serum P concentration curve; Study 2: 10 healthy participants consumed 4 different test meals (low, medium, or high PI meals or a control) over a 5-day period.
Results: Study 1 showed milk and dairy products had high PI values, pork and ham had medium PI values, and soy and tofu had low PI values. In Study 2, ingestion of high PI test meals showed higher fasting serum intact fibroblast growth factor 23 levels and lower serum 1,25-dihydroxyvitamin D levels compared with ingestion of low PI test meals.
Conclusion: These findings suggest that the PI can usefully evaluate the dietary P load of various foods and may help to make appropriate food choices for dietary P restriction in CKD patients.
Journal Title
Journal of Renal Nutrition
ISSN
10512276
NCID
AA10814783
Publisher
Elsevier|National Kidney Foundation
Volume
30
Issue
6
Start Page
493
End Page
502
Published Date
2020-08-07
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yoko Narasakiの学位論文として提出され, 学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3417号
Diploma Number
甲栄第278号
Granted Date
2020-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences