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ID 118251
Author
Hori, Taiki Tokushima University|Anan Medical Center
Yasui, Saya Anan Medical Center
Hosoki, Minae Anan Medical Center
Mitsui, Yukari Tokushima University
Masuda, Shiho Tokushima University
Otoda, Toshiki Tokushima University
Keywords
Phase angle
Extracellular water-to-total body water ratio
Skeletal muscle mass index
Bioelectrical impedance analysis
Hemoglobin
Hematocrit
Content Type
Journal Article
Description
Background: Anemia is one of the common complications of diabetes and is associated with mortality. Phase angle (PhA), ratio of extracellular water to total body water (ECW/TBW) and skeletal muscle mass index (SMI) estimated by bioelectrical impedance analysis (BIA) have been used as prognostic indicators for various chronic diseases and frailty. We aimed to clarify the clinical significance of PhA, ECW/TBW and SMI for anemia in patients with diabetes.
Materials and methods: The values of PhA, ECW/TBW and SMI were estimated by a portable BIA device and blood samples were collected in 371 Japanese patients with diabetes. The relationships of PhA, ECW/TBW and SMI with hemoglobin (Hgb) and hematocrit (Hct) were statistically evaluated.
Results: In simple linear regression analysis, PhA and SMI were positively correlated with Hgb and Hct levels in total subjects, male subjects and female subjects. In contrast, ECW/TBW was negatively correlated with Hgb and Hct levels regardless of sex. Multivariate regression analysis showed that both PhA and ECW/TBW but not SMI independently contributed to Hgb and Hct levels after adjustment of clinical confounding factors in both males and females.
Conclusions: PhA and ECW/TBW but not SMI were associated with levels of Hgb and Hct in patients with diabetes. Therefore, aberrant values of PhA and ECW/TBW suggest a risk of anemia in diabetic patients.
Journal Title
Heliyon
ISSN
24058440
Publisher
Elsevier
Volume
9
Issue
4
Start Page
e14724
Published Date
2023-03-21
Rights
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences
University Hospital
Institute of Advanced Medical Sciences