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ID 114358
Title Alternative
Loss of Heterozygosity in Pheochromocytomas
Author
Yokogoshi, Yutaka The University of Tokushima
Saito, Shiro The University of Tokushima
Keywords
Pheochromocytoma
Loss of heterozygosity
Oncogene
Chromosome 11
Content Type
Journal Article
Description
Molecular genetic analysis was performed with 20 oncogene probes and 32 polymorphic DNA probes on tumor DNA samples from seven pheochromocytomas; namely, one multiple endocrine neoplasia type 2B, and two familial and four sporadic pheochromocytomas. No amplification or rearrangement of the oncogenes was detected in any of the tumors. However, loss of heterozygosity on chromosome 1p, 11p or 11q was detected in these cases. In addition, a locus related to ETS1 was deleted in two of the sporadic tumors. These results suggest that pheochromocytomas may be genetically heterogeneous, and that inactivation of unknown genes on chromosome 1p, 11p or 11q may contribute to their development.
Journal Title
Japanese Journal of Cancer Research
NCID
AA00690844
Publisher
Japanese Cancer Association|John Wiley & Sons
Volume
81
Issue
6-7
Start Page
632
End Page
638
Published Date
1990-06
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences