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ID 116469
Title Alternative
CHOROIDAL STRUCTURE IN RP
Author
Niki, Masanori Tokushima University|Japan Clinical Retina Study Group Tokushima University Educator and Researcher Directory
Sano, Hiroki Tokushima University|Japan Clinical Retina Study Group
Miura, Gen Chiba University
Chiba, Akihiro Chiba University
Yamamoto, Shuichi Chiba University
Sonoda, Shozo Japan Clinical Retina Study Group|Kagoshima University
Sakamoto, Taiji Japan Clinical Retina Study Group|Kagoshima University
Keywords
binarization
choroidal structure
ellipsoid zone
enhanced depth imaging optical coherence tomography
retinitis pigmentosa
visual function
Content Type
Journal Article
Description
Purpose: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions.
Methods: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer.
Results: In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005).
Conclusion: The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP.
Journal Title
RETINA
ISSN
0275004X
15392864
NCID
AA10639923
AA12543461
Publisher
Ophthalmic Communications Society|Wolters Kluwer
Volume
39
Issue
12
Start Page
2399
End Page
2409
Published Date
2019-12
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND)(https://creativecommons.org/licenses/by-nc-nd/4.0/), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
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language
eng
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departments
Medical Sciences