number of access : ?
number of downloads : ?
ID 115585
Author
Sato, Hideo Tokushima University
Nakamura, Tenta Tokushima University
Hamada, Mai Tokushima University
Nagano, Shuji Tokushima University
Kameyama, Shuhei Tokushima University
Furue, Yui Kyoto Pharmaceutical University
Hayashi, Naoki Kyoto Pharmaceutical University
Kamoshida, Go Kyoto Pharmaceutical University
Oda, Masataka Kyoto Pharmaceutical University
Keywords
antibiotics
natural product
P. gingivalis
methicillin-resistant S. aureus
Content Type
Journal Article
Description
Side-chain derivatives of eurotiumide A, a dihydroisochroman-type natural product, have been synthesized and their antimicrobial activities described. Sixteen derivatives were synthesized from a key intermediate of the total synthesis of eurotiumide A, and their antimicrobial activities against two Gram-positive bacteria, methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA), and a Gram-negative bacterium, Porphyromonas gingivalis, were evaluated. The results showed that derivatives having an iodine atom on their aromatic ring instead of the prenyl moiety displayed better antimicrobial activity than eurotiumide A against MSSA and P. gingivalis. Moreover, we discovered that a derivative with an isopentyl side chain, which is a hydrogenated product of eurotiumide A, is the strongest antimicrobial agent against all three strains, including MRSA.
Journal Title
Marine Drugs
ISSN
16603397
Publisher
MDPI
Volume
18
Issue
2
Start Page
92
Published Date
2020-01-30
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences