| ID | 115033 |
| Author |
Takamura, Yoshihiro
University of Fukui
Shimura, Masahiko
Tokyo Medical University
Someya, Hideaki
National Defense Medical College
Sugimoto, Masahiko
Mie University
Hirano, Takao
Shinshu University
Sakamoto, Taiji
Kagoshima University
Gozawa, Makoto
University of Fukui
Matsumura, Takehiro
University of Fukui
Inatani, Masaru
University of Fukui
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| Content Type |
Journal Article
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| Description | Background/Aims
To investigate whether intravitreal injection of triamcinolone acetonide (IVTA) combined with vitrectomy prevents postoperative inflammation in patients with vitreous haemorrhage (VH) due to proliferative diabetic retinopathy (PDR). Methods This prospective, multicentre, randomised study conducted at seven sites in Japan enrolled patients diagnosed as having VH following PDR. Patients underwent vitrectomy with (IVTA+VIT group) or without (VIT group) IVTA at the end of the surgery. Anterior flare intensity (AFI), central retinal thickness (CRT), best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were measured before and at 3 days, 1 week, 1, 3 and 6 months after surgery and compared. Results Number of patients who completed 6 months of follow-up was 40 and 41 in VIT group and IVTA+VIT group, respectively. AFI was significantly higher in the VIT group than in the IVTA+VIT group at 3 days (P=0.033), 1 week (P=0.019) and 1 month (P=0.037). There were no significant differences in CRT, BCVA and IOP between the groups through the observational periods. In the cases with macular oedema >350 µm of CRT at 3 days, CRT was significantly lower in the IVTA+VIT group than in the VIT group at 1 month (P=0.041). Conclusions IVTA combined with vitrectomy and cataract surgery contributed to inhibit the postoperative inflammation in patients with VH due to PDR. The effect of IVTA in the reduction of diabetic macular oedema may be limited to the early stage after surgery. |
| Journal Title |
British Journal of Ophthalmology
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| ISSN | 00071161
14682079
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| NCID | AA00574774
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| Publisher | BMJ Publishing Group
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| Volume | 102
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| Issue | 10
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| Start Page | 1351
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| End Page | 1357
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| Published Date | 2018-01-17
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| Rights | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
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| language |
eng
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| TextVersion |
Publisher
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| departments |
University Hospital
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