てんかん患者と健常成人の視覚性誘発電位(VEP)の差異

The differences between epileptics and healthy subjects on the visual evoked potential (VEP) were studied. VEPs were recorded through the two derivations (2 ch : O 1→A 1+2, 5 ch : O 1→Cz). The differences in the latencies and interpeak amplitudes were compared and tested statistically, respectively for each sex, with special reference to the drugs been administered.
1. The latencies of VEP components in epileptics were longer than those in healthy subjects, in both sexes.
2. Interpeak amplitudes of VEP components in epileptics were smaller than those in healthy subjects, especially in late components, in both sexes.
3. These tendencies were more marked in males than in females.
4. In epileptics, between the subjects being administered each drug (CBZ, PB, VPA or PHT) or not, significant differences in latencies and intrerpeak amplitudes were not confirmed, with the components in which significant differences in latencies and amplitudes between epileptics and healthy subjects were found.
We verified the significant differences in VEPs between epileptics and healthy subjects, which suggested the dysfunction in epileptics in its brain stem and lateral geniculate body, even not considering the seizure types nor epileptic focus sites.