| ID | 72821 |
| Author |
Nagao, Tamiko
Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamashita, Tomoki
Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
Miyake, Ariko
Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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Uchiyama, Tsuneo
Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
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Nomaguchi, Masako
Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
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Adachi, Akio
Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
Tokushima University Educator and Researcher Directory
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|
| Keywords | HIV-1
Vif
APOBEC3G
APOBEC3F
|
| Content Type |
Journal Article
|
| Description | We examined a series of site-directed point mutants of human immunodeficiency virus type 1 (HIV-1) Vif for their interaction with cellular anti-viral factors APOBEC3G/APOBEC3F. Mutant viruses that display growth-defect in H9 cells did not counteract effectively APOBEC3G and/or APOBEC3F without exception, as monitored by single-cycle infectivity assays. While growth-defective mutants of Vif C-terminal region were unable to suppress APOBEC3G/APOBEC3F, some N-terminal region mutants did neutralize one of APOBEC3G/APOBEC3F. These data have suggested that members of APOBEC3 family other than APOBEC3G/APOBEC3F are not important for anti-HIV-1 activity. Furthermore, APOPEC3G/APOBEC3F were found to differently associate with Vif in virions as analyzed by equilibrium density centrifugation. Taken together, these results indicated that interaction of HIV-1 Vif and APOBEC3G is distinct from that between Vif and APOBEC3F.
|
| Journal Title |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| NCID | AA11166929
|
| Volume | 57
|
| Issue | 1-2
|
| Start Page | 89
|
| End Page | 94
|
| Sort Key | 89
|
| Published Date | 2010-02
|
| Remark | The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
|
| EDB ID | |
| FullText File | |
| language |
eng
|
| departments |
Medical Sciences
|
