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ID 114872
Author
Fujii, Emiko The University of Tokushima
Miyazaki, Masahito The University of Tokushima
Hashimoto, Toshiaki Japanese Red Cross Tokushima Hinomine Rehabilitation
Keywords
Autistic spectrum disorders (ASD)
123I-iomazenil SPECT
γ-Aminobutyric acid (GABA)
Epilepsy
Content Type
Journal Article
Description
Purpose:
To evaluate the GABAA receptor in the autistic brain, we performed 123I-IMZ SPECT in patients with ASD. We compared 123I-IMZ SPECT abnormalities in patients who showed intellectual disturbance or focal epileptic discharge on EEG to those in patients without such findings.
Subjects and methods:
The subjects consisted of 24 patients with ASD (mean age, 7.3±3.5years), including 9 with autistic disorder (mean age, 7.0±3.7years) and 15 with Asperger’s disorder (mean age, 7.5±3.2years). We used 10 non-symptomatic partial epilepsy patients (mean age, 7.8±3.6years) without intellectual delay as a control group.
For an objective evaluation of the 123I-IMZ SPECT results, we performed an SEE (Stereotactic Extraction Estimation) analysis to describe the decrease in accumulation in each brain lobule numerically.
Results
In the comparison of the ASD group and the control group, there was a dramatic decrease in the accumulation of 123I-IMZ in the superior and medial frontal cortex. In the group with intellectual impairment and focal epileptic discharge on EEG, the decrease in accumulation in the superior and medial frontal cortex was greater than that in the group without these findings.
Conclusion
The present results suggest that disturbance of the GABAergic nervous system may contribute to the pathophysiology and aggravation of ASD, since the accumulation of 123I-IMZ was decreased in the superior and medial frontal cortex, which is considered to be associated with inference of the thoughts, feelings, and intentions of others (Theory of Mind).
Journal Title
Brain and Development
ISSN
03877604
NCID
AA00111153
AA11521714
Publisher
The Japanese Society of Child Neurology|Elsevier
Volume
34
Issue
8
Start Page
648
End Page
654
Published Date
2011-11-17
Rights
© 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
University Hospital
Medical Sciences