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ID 116930
Author
Weng, Yao Okayama University
He, Yuhan Okayama University
Shiotsu, Noriko Okayama University
Ikegame, Mika Okayama University
Uchida-Fukuhara, Yoko Okayama University
Tanai, Airi Okayama University
Guo, Jiajie Okayama University|China Medical University
Keywords
Extracellular vesicles
Outer membrane vesicles
Porphyromonas gingivalis
Host cell interaction
In vivo imaging
Content Type
Journal Article
Description
Extracellular vesicles (EVs) have been recognized as a universal method of cellular communications and are reportedly produced in bacteria, archaea, and eukaryotes. Bacterial EVs are often called “Outer Membrane Vesicles” (OMVs) as they were the result of a controlled blebbing of the outer membrane of gram-negative bacteria such as Porphyromonas gingivalis (P. gingivalis). Bacterial EVs are natural messengers, implicated in intra- and inter-species cell-to-cell communication among microorganism populations present in microbiota. Bacteria can incorporate their pathogens into OMVs; the content of OMVs differs, depending on the type of bacteria. The production of distinct types of OMVs can be mediated by different factors and routes. A recent study highlighted OMVs ability to carry crucial molecules implicated in immune modulation, and, nowadays, they are considered as a way to communicate and transfer messages from the bacteria to the host and vice versa. This review article focuses on the current understanding of OMVs produced from major oral bacteria, P. gingivalis: generation, characteristics, and contents as well as the involvement in signal transduction of host cells and systemic diseases. Our recent study regarding the action of P. gingivalis OMVs in the living body is also summarized.
Journal Title
Japanese Dental Science Review
ISSN
18827616
NCID
AA12334461
Publisher
Japanese Association for Dental Science|Elsevier
Volume
57
Start Page
138
End Page
146
Published Date
2021-08-26
Rights
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences