ID | 116163 |
Author |
Nakai, Hiroki
Tokushima University
Akiyama, Daiu
Tokushima University
Taniguchi, Yoshiaki
Tokushima University
Kishinobu, Iori
Tokushima University
Wariishi, Hiromichi
Tokushima University
Ohno, Yasuhide
Tokushima University
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Nagase, Masao
Tokushima University
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Ikeda, Takuya
Tokushima University
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Content Type |
Journal Article
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Description | Charge-independent biomolecule detection using field-effect transistors (FETs) with single-crystal and large-area epitaxial graphene films fabricated on SiC substrates is demonstrated. To obtain clean graphene channel surfaces, FETs were fabricated using stencil mask lithography, which is a resist-free fabrication process. Proteins with various isoelectric points (pI: 5.6โ9.9) were used as targets. Transfer characteristics [drain current (๐ผD) vs solution-gate voltage (๐G) characteristics] were measured by changing the pH of the buffer solution. The ๐ผDโ๐G characteristics exhibited a clear negative gate voltage shift for both positively and negatively charged proteins, indicating that the epitaxial graphene FETs could not detect the charge type of the protein and electrons were doped by the adsorption of both positively and negatively charged proteins. These results cannot be explained by conventional electrostatic effects. Therefore, it can be concluded that the detection of biomolecules by the epitaxial graphene FETs occurred through charge transfer from the proteins. Moreover, the dissociation constants between the proteins and epitaxial graphene films were as small as 100โpM, indicating the high sensitivity of the graphene FETs.
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Journal Title |
Journal of Applied Physics
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ISSN | 00218979
10897550
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NCID | AA00693547
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Publisher | AIP Publishing
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Volume | 130
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Issue | 7
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Start Page | 074502
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Published Date | 2021-08-16
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Remark | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Journal of Applied Physics 130, 074502 (2021) and may be found at https://doi.org/10.1063/5.0054688.
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Science and Technology
Bioscience and Bioindustry
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