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ID 116163
Author
Nakai, Hiroki Tokushima University
Akiyama, Daiu Tokushima University
Taniguchi, Yoshiaki Tokushima University
Kishinobu, Iori Tokushima University
Wariishi, Hiromichi Tokushima University
Ikeda, Takuya Tokushima University
Content Type
Journal Article
Description
Charge-independent biomolecule detection using field-effect transistors (FETs) with single-crystal and large-area epitaxial graphene films fabricated on SiC substrates is demonstrated. To obtain clean graphene channel surfaces, FETs were fabricated using stencil mask lithography, which is a resist-free fabrication process. Proteins with various isoelectric points (pI: 5.6โ€“9.9) were used as targets. Transfer characteristics [drain current (๐ผD) vs solution-gate voltage (๐‘‰G) characteristics] were measured by changing the pH of the buffer solution. The ๐ผDโ€“๐‘‰G characteristics exhibited a clear negative gate voltage shift for both positively and negatively charged proteins, indicating that the epitaxial graphene FETs could not detect the charge type of the protein and electrons were doped by the adsorption of both positively and negatively charged proteins. These results cannot be explained by conventional electrostatic effects. Therefore, it can be concluded that the detection of biomolecules by the epitaxial graphene FETs occurred through charge transfer from the proteins. Moreover, the dissociation constants between the proteins and epitaxial graphene films were as small as 100โ€‰pM, indicating the high sensitivity of the graphene FETs.
Journal Title
Journal of Applied Physics
ISSN
00218979
10897550
NCID
AA00693547
Publisher
AIP Publishing
Volume
130
Issue
7
Start Page
074502
Published Date
2021-08-16
Remark
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Journal of Applied Physics 130, 074502 (2021) and may be found at https://doi.org/10.1063/5.0054688.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Science and Technology
Bioscience and Bioindustry