メタボリックシンドロームと肥満

It is well-known that obesity causes several disease, especially, cardiovascular disease. The metabolic syndrome-the cluster of obesity, impaired fasting glucose, elevated triglycerides, low high-density lipoprotein cholesterol, and hypertension, has been identified as an independent risk factor for cardiovascular disease. In this syndrome, abdominal obesity play a critical role for development of insulin resistance and atherosclerosis. Recently it is reported that visceral fat accumulation brings impaired adipocytokine environment such as increase of inflammatory cytokine and decrease of adiponectin. On the other hand, adipose tissue has an ability to activate cortisone that causes steroid excess in peripheral tissue. Though it seems to need some reevaluation, waist circumference is an useful biomarker for clinical intervention in the metabolic syndrome which aims to avoid the development of cardiovascular disease.