ID | 118821 |
Title Alternative | Molecular mechanisms of acute radiation intestinal injury and its control
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Author |
Morita, Akinori
Tokushima University
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Sakai, Takuma
Tokushima University
Higashi, Yuichi
Tokushima University
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Keywords | 放射線防護剤
p53
p53調節剤
炎症応答
炎症制御
radioprotector
p53 modulator
inflammatory response
inflammation control
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Content Type |
Journal Article
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Description | 腸管は代表的な放射線高感受性組織であり、放射線治療においては腹部・骨盤領域の腫瘍への処方線量を制限するリスク臓器である。高線量の放射線により腸組織が損傷を受けると腸上皮幹細胞の喪失を誘発するが、この過程はp53 によって制御される陰窩細胞死過程と炎症性の免疫応答による増悪過程の2 段階のプロセスからなることが明らかにされつつある。本総説では、それぞれの過程の分子機構について概説し、急性放射線腸管障害を効果的に制御する方法について考察する。
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Description Alternative | The intestinal tract is a typical radiosensitive tissue and a risk organ in radiotherapy that limits the prescribed dose to tumors in the abdominal and pelvic regions. High-dose radiation damage to intestinal tissue induces loss of intestinal stem cells, and it is becoming clear that this process consists of two steps: a crypt cell death process regulated by p53 and an exacerbation process by inflammatory immune responses. In this review, we will outline the molecular mechanisms of each process and discuss how to effectively control acute radiation intestinal injury.
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Journal Title |
Radiation Biology Research Communications
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ISSN | 0441747X
21869766
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NCID | AN00225482
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Publisher | 放射線生物研究会
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Volume | 58
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Issue | 2
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Start Page | 93
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End Page | 109
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Published Date | 2023-06
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EDB ID | |
FullText File | |
language |
jpn
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TextVersion |
Publisher
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departments |
Medical Sciences
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