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ID 115932
Title Alternative
血液がん患者の好中球減少に伴う発熱の危険因子としての口腔細菌および口腔免疫との関連
Risk factors for chemotherapy-induced fever with neutropenia
Author
Sogawa, Yuka Tokushima University|Tokushima Bunri University
Yoshioka, Masami Tokushima Bunri University KAKEN Search Researchers
Keywords
Fever with neutropenia
Hematological cancer
Risk factor
Secretory immunoglobulin A
Fusobacterium nucleatum
Content Type
Thesis or Dissertation
Description
The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1,500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject was assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p<0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p<0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cut-off point based on the AUC in the F. nucleatum / sIgA ratio was 0.023, and this model had a 78.4% probability (p<0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum / sIgA ratio (HR 66.06, p<0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors.
Journal Title
International Journal of Hematology
ISSN
09255710
18653774
NCID
AA10797094
Publisher
Japanese Society of Hematology|Springer Nature
Volume
112
Issue
6
Start Page
851
End Page
859
Published Date
2020-09-03
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuka Sogawaの学位論文として提出され,学位審査・授与の対象となっている。
著者の申請により要約(2021-04-27公開)に替えて論文全文を公開(2022-12-16)
Rights
© Japanese Society of Hematology 2020
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12185-020-02975-x
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3472号
Diploma Number
甲口保第5号
Granted Date
2021-02-08
Degree Name
Doctor of Oral Health Science
Grantor
Tokushima University
departments
Oral Sciences
Medical Sciences
University Hospital