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ID 117528
Title Alternative
ヒト白血病K562細胞でクロトリマゾールにより誘発される細胞死に対するマイクロモル濃度の亜鉛の影響
Author
Kobayashi, Masako The University of Tokushima
Sakanashi, Yoko The University of Tokushima
Matsui, Hiroko The University of Tokushima
Nishimura, Yumiko The University of Tokushima
Kanemaru, Kaori The University of Tokushima KAKEN Search Researchers
Okano, Yoshiro Tokushima Bunri University
Oyama, Yasuo The University of Tokushima KAKEN Search Researchers
Keywords
clotrimazole
zinc
cytotoxicity
human leukemia K562 cells
Content Type
Departmental Bulletin Paper
Description
Our recent study showed that the simultaneous application of clotrimazole with CdCI2 or PbCI2 exerted potent cytotoxic action in rat thymocytes although respective agents were ineffective. It was also the case of ZnCl2 and clotrimazole in preliminary study using rat thymocytes. Since clotrimazole is supposed to be a candidate for anticancer drug, we examined the effects of clotrimazole, ZnCI2, and their combination on human leukemia K562 cells. The combination of clotrimazole and ZnCl2 exerted potent cytotoxic effects on the growth and lethality of K562 cells by presumably modifying the process of cell death. The result suggests the possibility that endogenous Zn2+ may modify the action of clotrimazole.
Journal Title
Natural Science Research
ISSN
09146385
NCID
AN10065859
Publisher
徳島大学総合科学部
Volume
21
Start Page
1
End Page
8
Sort Key
1
Published Date
2007-12-21
EDB ID
FullText File
nsr_21_1.pdf 1.09 MB
language
eng
TextVersion
Publisher
departments
Bioscience and Bioindustry