ID | 115675 |
Title Alternative | 尿中アディポネクチン排泄は糖尿病患者における腎機能低下の早期予測指標である。
Urinary adiponectin in DKD
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Author |
Mori, Hiroyasu
Tokushima University
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Ohishi, Mami
Tokushima University
Kuroda, Akio
Tokushima University
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Akehi, Yuko
Tokushima University
Yoshida, Sumiko
Tokushima University
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Aihara, Ken-ichi
Tokushima University
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Aiba, Motohiro
Tokushima Bunri University
Kawano, Tomoharu
Tokushima Bunri University
Hashida, Seiichi
Ehime University
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Keywords | diabetes kidney disease
urinary adiponectin
estimated glomerular filtration rate
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Content Type |
Thesis or Dissertation
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Description | Aims: Since diabetes-associated kidney complication changes from diabetic nephropathy to diabetic kidney disease (DKD), more suitable biomarkers than urinary albumin are required. It has been hypothesized that urinary adiponectin (u-ADPN) is associated with the progression of DKD. We therefore evaluated the effectiveness of u-ADPN in predicting the decline of the renal function in patients with diabetes prior to end-stage renal disease.
Methods: An ultrasensitive immune complex transfer enzyme immunoassay (ICT-EIA) was used to measure total and high molecular weight (HMW) adiponectin separately. We evaluated the relationships between the creatinine-adjusted urinary total-ADPN and HMW-ADPN, albumin (UACR) and liver-type fatty acid binding protein (L-FABP) at baseline and the 2-year change of the estimated glomerular filtration rate (ΔeGFR). Results: This 2-year prospective observational study included 201 patients with diabetes. These patients were divided into three groups according to their ΔeGFR: ≤-10 ml/min/1.73m2, >-10 and ≤0 ml/min/1.73m2, and >0 ml/min/1.73m2. Jonckheere-Terpstra test showed that lower ΔeGFR was associated with higher u-HMW-ADPN (p = 0.045). In logistic regression analysis, u-HMW-ADPN was associated with ΔeGFR after adjusted age, sex, and basal eGFR. Conclusion: Urinary HMW-ADPN could predict a declining renal function in patients with diabetes. |
Journal Title |
Journal of Diabetes and its Complications
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ISSN | 10568727
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NCID | AA10843748
AA11531864
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Publisher | Elsevier
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Volume | 35
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Issue | 4
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Start Page | 107848
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Published Date | 2021-01-07
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は,著者Masashi Ishizuの学位論文として提出され,学位審査・授与の対象となっている。 |
Rights | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3503号
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Diploma Number | 甲医第1489号
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Granted Date | 2021-03-23
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
Institute of Advanced Medical Sciences
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