| ID | 114985 |
| Author |
Kawamura, Yusuke
National Defense Medical College
Nakaoka, Hirofumi
National Institute of Genetics
Nakayama, Akiyoshi
National Defense Medical College|Japan Air Self-Defense Force
Okada, Yukinori
Osaka University|RIKEN Center for Integrative Medical Sciences
Yamamoto, Ken
Kurume University
Higashino, Toshihide
National Defense Medical College
Sakiyama, Masayuki
National Defense Medical College
Shimizu, Toru
Midorigaoka Hospital|Kyoto Industrial Health Association
Ooyama, Hiroshi
Ryougoku East Gate Clinic
Ooyama, Keiko
Ryougoku East Gate Clinic
Nagase, Mitsuo
Nagase Clinic
Hidaka, Yuji
Akasaka Central Clinic
Shirahama, Yuko
Kurume University
Hosomichi, Kazuyoshi
Kanazawa University
Nishida, Yuichiro
Saga University
Shimoshikiryo, Ippei
Kagoshima University
Hishida, Asahi
Nagoya University
Katsuura-Kamano, Sakurako
The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Shimizu, Seiko
National Defense Medical College
Kawaguchi, Makoto
National Defense Medical College
Ibusuki, Rie
Kagoshima University
Hara, Megumi
Saga University
Naito, Mariko
Nagoya University|Hiroshima University
Takao, Mikiya
National Defense Medical College
Nakajima, Mayuko
National Defense Medical College
Iwasawa, Satoko
National Defense Medical College
Nakashima, Hiroshi
National Defense Medical College
Ohnaka, Keizo
Kyushu University
Nakamura, Takahiro
National Defense Medical College
Stiburkova, Blanka
Institute of Rheumatology, Prague|Charles University
Merriman, Tony R
University of Otago
Nakatochi, Masahiro
Nagoya University
Ichihara, Sahoko
Jichi Medical University
Yokota, Mitsuhiro
Aichi Gakuin University
Takada, Tappei
The University of Tokyo
Kamatani, Yoichiro
RIKEN Center for Integrative Medical Sciences|Kyoto University
Takahashi, Atsushi
RIKEN Center for Integrative Medical Sciences|National Cerebral and Cardiovascular Center
Arisawa, Kokichi
The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Takezaki, Toshiro
Kagoshima University
Tanaka, Keitaro
Saga University
Wakai, Kenji
Nagoya University
Kubo, Michiaki
RIKEN Center for Integrative Medical Sciences
Hosoya, Tatsuo
Jikei University School of Medicine
Ichida, Kimiyoshi
Jikei University School of Medicine|Tokyo University of Pharmacy and Life Sciences
Inoue, Ituro
National Institute of Genetics
Shinomiya, Nariyoshi
National Defense Medical College
Matsuo, Hirotaka
National Defense Medical College
|
| Content Type |
Journal Article
|
| Description | Objective
The first ever genome-wide association study (GWAS) of clinically defined gout cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout loci that aggravate AHUA into gout. Methods We carried out a GWAS of 945 clinically defined gout cases and 1003 AHUA controls followed by 2 replication studies. In total, 2860 gout cases and 3149 AHUA controls (all Japanese men) were analysed. We also compared the ORs for each locus in the present GWAS (gout vs AHUA) with those in the previous GWAS (gout vs normouricaemia). Results This new approach enabled us to identify two novel gout loci (rs7927466 of CNTN5 and rs9952962 of MIR302F) and one suggestive locus (rs12980365 of ZNF724) at the genome-wide significance level (p<5.0×10– 8). The present study also identified the loci of ABCG2, ALDH2 and SLC2A9. One of them, rs671 of ALDH2, was identified as a gout locus by GWAS for the first time. Comparing ORs for each locus in the present versus the previous GWAS revealed three ‘gout vs AHUA GWAS’-specific loci (CNTN5, MIR302F and ZNF724) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. Conclusions This meta-analysis is the first to reveal the loci associated with crystal-induced inflammation, the last step in gout development that aggravates AHUA into gout. Our findings should help to elucidate the molecular mechanisms of gout development and assist the prevention of gout attacks in high-risk AHUA individuals. |
| Journal Title |
Annals of the Rheumatic Diseases
|
| ISSN | 00034967
14682060
|
| NCID | AA00533085
AA12778137
|
| Publisher | BMJ Publishing Group
|
| Volume | 78
|
| Issue | 10
|
| Start Page | 1430
|
| End Page | 1437
|
| Published Date | 2019-07-08
|
| Rights | This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
|
| TextVersion |
Publisher
|
| departments |
Medical Sciences
Institute of Advanced Medical Sciences
|
